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| Item Type: | Article |
|---|---|
| Title: | An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect |
| Creators Name: | Fraga-Silva, R.A. and Costa-Fraga, F.P. and Sousa, F.B. and Alenina, N. and Bader, M. and Sinisterra, R.D. and Santos, R.A. |
| Abstract: | The heptapeptide angiotensin-(1-7) is a component of the renin-angiotensin system, which promotes many beneficial cardiovascular effects, including antithrombotic activity. We have recently shown that the antithrombotic effect of angiotensin-(1-7) involves receptor Mas-mediated NO-release from platelets. Here, we describe an orally active formulation based on angiotensin-(1-7) inclusion in cyclodextrin [Ang-(1-7)- CyD] as an antithrombotic agent. Cyclodextrins are pharmaceutical tools that are used to enhance drug stability, absorption across biological barriers and gastric protection. |
| Keywords: | Angiotensin-(1-7), Renin-Angiotensin-System, Receptor Mas, Antithrombotic, Cyclodextrin, Animals, Mice, Rats |
| Source: | Clinics |
| ISSN: | 1807-5932 |
| Publisher: | University of Sao Paulo, Faculty of Medicine |
| Volume: | 66 |
| Number: | 5 |
| Page Range: | 837-841 |
| Date: | 2011 |
| Official Publication: | https://doi.org/10.1590/S1807-59322011000500021 |
| PubMed: | View item in PubMed |
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