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Discovery of a novel tumour metastasis-promoting gene, NVM-1

Item Type:Article
Title:Discovery of a novel tumour metastasis-promoting gene, NVM-1
Creators Name:Thiele, W. and Novac, N. and Mink, S. and Schreiber, C. and Plaumann, D. and Fritzmann, J. and Cremers, N. and Rothley, M. and Schwager, C. and Regiert, T. and Huber, P.E. and Stein, U. and Schlag, P. and Moll, J. and Abdollahi, A. and Sleeman, J.P.
Abstract:We have previously reported that over-expression of a panel of 119 genes correlates with the metastatic potential of pancreatic carcinoma cells. We sought to identify and functionally characterize candidate tumour metastasis promoting genes among this library using a secondary phenotype-assisted screen. Here we report the discovery of the metastasis-promoting function of a hitherto not characterized gene located on chromosome 14 (ORF138), which we have named 'novel metastasis-promoting gene 1' (NVM-1). The NVM-1 transcript is extensively alternatively spliced, is expressed endogenously in a number of different tissues, and is strongly over-expressed at the protein level in a variety of human tumour types. Importantly, NVM-1 expression stimulates the migratory and invasive behaviour of tumour cells and promotes metastasis formation in experimental animals in vivo. Up-regulation of FMNL2 and MT1E and down-regulation of TIMP4 and MHC-I is observed as a consequence of NVM-1 expression. Together these data identify NVM-1 as a gene that is functionally involved in tumour metastasis, and suggest that NVM-1 may constitute a promising therapeutic target for inhibition of tumour metastasis.
Keywords:Tumour, Metastasis, Motility, Dissemination, Invasion, Animals, Mice
Source:Journal of Pathology
Publisher:Wiley-Blackwell (U.K.)
Page Range:96-105
Date:September 2011
Official Publication:https://doi.org/10.1002/path.2924
PubMed:View item in PubMed

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