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WNT/beta-catenin signaling in polycystic kidney disease

Item Type:Editorial
Title:WNT/beta-catenin signaling in polycystic kidney disease
Creators Name:Wuebken, A. and Schmidt-Ott, K.M.
Abstract:Cystic kidney diseases have been linked to defective WNT signal transduction. Perturbations of cystic disease genes cause activation of canonical WNT/beta-catenin/TCF/Lef1 signaling in model organisms and cultured cells. Inappropriate levels of WNT/beta-catenin signaling cause renal cyst formation in mice. These observations have prompted the idea that an activation of WNT/beta-catenin signaling may constitute a common causative event in cyst formation. Now this view is challenged by key genetic mouse models of cystic kidney disease that do not display WNT/beta-catenin activity in cyst-lining epithelia.
Keywords:Cysts, Autosomal Dominant Polycystic Kidney, TCF Transcription Factors, beta Catenin, Animals
Source:Kidney International
Publisher:Nature Publishing Group
Page Range:135-138
Date:July 2011
Official Publication:https://doi.org/10.1038/ki.2011.87
PubMed:View item in PubMed

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