Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development

Item Type:	Article
Title:	Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development
Creators Name:	Loewer, A. and Soba, P. and Beyreuther, K. and Paro, R. and Merdes, G.
Abstract:	The cleavage of proteins within their transmembrane domain by Presenilin (PS) has an important role in different signalling pathways and in Alzheimer's disease. Nevertheless, not much is known about the regulation of PS activity. It has been suggested that substrate recognition by the PS complex depends only on the size of the extracellular domain independent of the amino-acid sequence and that PS activity is constitutive in all cells that express the minimal components of the complex. We report here the development of an in vivo reporter system that allowed us to analyse the processing of human amyloid precursor protein (APP) and the Notch receptor tissue specifically during Drosophila development in the living organism. Using this system, we demonstrate differences between APP and Notch processing and show that PS-mediated cleavage of APP can be regulated in different cell types independent of the size of the extracellular domain.
Keywords:	Amyloid beta-Protein Precursor, Drosophila Proteins, Eye, Membrane Proteins, Neurons, Presenilin-1, Presenilin-2, Notch Receptors, Wing, Animals, Drosophila
Source:	EMBO Reports
ISSN:	1469-221X
Publisher:	Nature Publishing Group
Volume:	5
Number:	4
Page Range:	405-411
Date:	April 2004
Official Publication:	https://doi.org/10.1038/sj.embor.7400122
PubMed:	View item in PubMed

Repository Staff Only: item control page