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The ups and downs of p53: understanding protein dynamics in single cells

Item Type:Article
Title:The ups and downs of p53: understanding protein dynamics in single cells
Creators Name:Batchelor, E. and Loewer, A. and Lahav, G.
Abstract:Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
Keywords:Calcium, Cell Cycle Proteins, Double-Stranded DNA Breaks, DNA Repair, DNA-Binding Proteins, Neoplasms, Post-Translational Protein Processing, Protein-Serine-Threonine Kinases, Signal Transduction, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Animals
Source:Nature Reviews Cancer
Publisher:Nature Publishing Group
Page Range:371-377
Date:May 2009
Official Publication:https://doi.org/10.1038/nrc2604
PubMed:View item in PubMed

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