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Functional significance of cleavable signal peptides of G protein-coupled receptors

Item Type:Review
Title:Functional significance of cleavable signal peptides of G protein-coupled receptors
Creators Name:Schuelein, R. and Westendorf, C. and Krause, G. and Rosenthal, W.
Abstract:About 5-10% of the G protein-coupled receptors (GPCRs) contain N-terminal signal peptides that are cleaved off by the signal peptidases of the endoplasmic reticulum (ER) during the translocon-mediated receptor insertion into the ER membrane. The reason as to why only a subset of the GPCRs requires these additional signal peptides was addressed in the past decade only by a limited number of studies. Recent progress suggests that signal peptides of GPCRs do not only serve the classical ER targeting and translocon gating functions as described for the signal peptides of secretory proteins. In the case of GPCRs, uncleaved pseudo signal peptides may regulate receptor expression at the plasma membrane and may also influence G protein coupling. Moreover, signal peptides of GPCRs seem to match functionally with sequences of the mature N tails. In this review, we summarize the current knowledge about cleavable signal peptides of GPCRs and address the question whether these sequences may be future drug targets in pharmacology.
Keywords:Signal Peptides, Signal Anchor Sequences, Translocon, G Protein-Coupled Receptors, Cotransin, Animals
Source:European Journal of Cell Biology
Publisher:Urban & Fischer
Page Range:294-299
Date:April 2012
Official Publication:https://doi.org/10.1016/j.ejcb.2011.02.006
PubMed:View item in PubMed

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