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Ca(2+)-activated Cl(-) currents are dispensable for olfaction

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Item Type:Article
Title:Ca(2+)-activated Cl(-) currents are dispensable for olfaction
Creators Name:Billig, G.M. and Pal, B. and Fidzinski, P. and Jentsch, T.J.
Abstract:Canonical olfactory signal transduction involves the activation of cyclic AMP-activated cation channels that depolarize the cilia of receptor neurons and raise intracellular calcium. Calcium then activates Cl(-) currents that may be up to tenfold larger than cation currents and are believed to powerfully amplify the response. We identified Anoctamin2 (Ano2, also known as TMEM16B) as the ciliary Ca(2+)-activated Cl(-) channel of olfactory receptor neurons. Ano2 is expressed in the main olfactory epithelium (MOE) and in the vomeronasal organ (VNO), which also expresses the related Ano1 channel. Disruption of Ano2 in mice virtually abolished Ca(2+)-activated Cl(-) currents in the MOE and VNO. Ano2 disruption reduced fluid-phase electro-olfactogram responses by only approximately 40%, did not change air-phase electro-olfactograms and did not reduce performance in olfactory behavioral tasks. In contrast with the current view, cyclic nucleotide-gated cation channels do not need a boost by Cl(-) channels to achieve near-physiological levels of olfaction.
Keywords:Calcium, Chloride Channels, Olfactory Receptor Neurons, Signal Transduction, Smell, Vomeronasal Organ, Animals, Mice
Source:Nature Neuroscience
ISSN:1097-6256
Publisher:Nature Publishing Group (U.S.A.)
Volume:14
Number:6
Page Range:763-769
Date:June 2011
Official Publication:https://doi.org/10.1038/nn.2821
PubMed:View item in PubMed

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