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Pathogenesis of non-Hodgkin's lymphoma

Official URL:https://doi.org/10.1200/JCO.2010.33.3252
PubMed:View item in PubMed
Creators Name:Nogai, H. and Doerken, B. and Lenz, G.
Journal Title:Journal of Clinical Oncology
Journal Abbreviation:J Clin Oncol
Volume:29
Number:14
Page Range:1803-1811
Date:10 May 2011
Keywords:B-Lymphocytes, Diffuse Large B-Cell Lymphoma, Follicular Lymphoma, Mantle-Cell Lymphoma, NF-kappa B, Non-Hodgkin Lymphoma, Signal Transduction
Abstract:The understanding of the molecular pathogenesis of non-Hodgkin's lymphomas (NHL) has significantly improved in recent years. Advances in molecular biology and genetics lead to the identification and characterization of several oncogenic pathways involved in lymphomagenesis. This knowledge will ultimately lead to improved diagnostic and therapeutic strategies for patients with NHL. This review summarizes current concepts of the molecular pathogenesis of the most common NHL subtypes, with a special emphasis on diffuse large B-cell lymphoma, the most common lymphoma subtype.
ISSN:0732-183X
Publisher:American Society of Clinical Oncology (U.S.A.)
Item Type:Review

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