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Importin alpha7 is essential for zygotic genome activation and early mouse development

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Item Type:Article
Title:Importin alpha7 is essential for zygotic genome activation and early mouse development
Creators Name:Rother, F. and Shmidt, T. and Popova, E. and Krivokharchenko, A. and Huegel, S. and Vilianovich, L. and Ridders, M. and Tenner, K. and Alenina, N. and Koehler, M. and Hartmann, E. and Bader, M.
Abstract:Importin alpha is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin alpha7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin alpha7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin alpha7 is a new member of the small group of maternal effect genes.
Keywords:Developmental Gene Expression Regulation, DNA Replication, Embryonic Development, Essential Genes, Gene Targeting, Genome, Mammalian Embryo, Nuclear Envelope, Oocytes, Ovary, Parthenogenesis, Zygote, alpha Karyopherins, Animals, Mice
Source:PLoS ONE
ISSN:1932-6203
Publisher:Public Library of Science (U.S.A.)
Volume:6
Number:3
Page Range:e18310
Date:March 2011
Official Publication:https://doi.org/10.1371/journal.pone.0018310
PubMed:View item in PubMed

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