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Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial

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Item Type:Article
Title:Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial
Creators Name:Duengen, H.D. and Apostolovic, S. and Inkrot, S. and Tahirovic, E. and Toepper, A. and Mehrhof, F. and Prettin, C. and Putnikovic, B. and Neskovic, A.N. and Krotin, M. and Sakac, D. and Lainscak, M. and Edelmann, F. and Wachter, R. and Rau, T. and Eschenhagen, T. and Doehner, W. and Anker, S.D. and Waagstein, F. and Herrmann-Lingen, C. and Gelbrich, G. and Dietz, R.
Abstract:AIMS: Various beta-blockers with distinct pharmacological profiles are approved in heart failure, yet they remain underused and underdosed. Although potentially of major public health importance, whether one agent is superior in terms of tolerability and optimal dosing has not been investigated. The aim of this study was therefore to compare the tolerability and clinical effects of two proven beta-blockers in elderly patients with heart failure. METHODS AND RESULTS: We performed a double-blind superiority trial of bisoprolol vs. carvedilol in 883 elderly heart failure patients with reduced or preserved left ventricular ejection fraction in 41 European centres. The primary endpoint was tolerability, defined as reaching and maintaining guideline-recommended target doses after 12 weeks treatment. Adverse events and clinical parameters of patient status were secondary endpoints. None of the beta-blockers was superior with regards to tolerability: 24% [95% confidence interval (CI) 20-28] of patients in the bisoprolol arm and 25% (95% CI 21-29) of patients in the carvedilol arm achieved the primary endpoint (P= 0.64). The use of bisoprolol resulted in greater reduction of heart rate (adjusted mean difference 2.1 b.p.m., 95% CI 0.5-3.6, P= 0.008) and more, dose-limiting, bradycardic adverse events (16 vs. 11%; P= 0.02). The use of carvedilol led to a reduction of forced expiratory volume (adjusted mean difference 50 mL, 95% CI 4-95, P= 0.03) and more, non-dose-limiting, pulmonary adverse events (10 vs. 4%; P < 0.001). CONCLUSION: Overall tolerability to target doses was comparable. The pattern of intolerance, however, was different: bradycardia occurred more often in the bisoprolol group, whereas pulmonary adverse events occurred more often in the carvedilol group. This study is registered with controlled-trials.com, number ISRCTN34827306.
Keywords:Heart Failure, Beta-Blocker, Elderly, Tolerability, Target Dose, Lung Function
Source:European Journal of Heart Failure
Publisher:Oxford University Press
Page Range:670-680
Date:June 2011
Official Publication:https://doi.org/10.1093/eurjhf/hfr020
PubMed:View item in PubMed

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