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Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood

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Item Type:Article
Title:Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood
Creators Name:Fricker, F.R. and Lago, N. and Balarajah, S. and Tsantoulas, C. and Tanna, S. and Zhu, N. and Fageiry, S.K. and Jenkins, M. and Garratt, A.N. and Birchmeier, C. and Bennett, D.L.
Abstract:Neuregulin-1 (NRG1) plays a crucial role in axoglial signaling during the development of the peripheral nervous system, but its importance in adulthood after peripheral nerve injury remains unclear. We used single-neuron labeling with inducible Cre-mediated knock-out animals, which enabled visualization of a subset of adult myelinated sensory and motoneurons neurons in which Nrg1 was inducibly mutated by tamoxifen treatment. In uninjured mice, NRG1-deficient axons and the associated myelin sheath were normal, and the neuromuscular junction demonstrated normal apposition of presynaptic and postsynaptic components. After sciatic nerve crush, NRG1 ablation resulted in severe defects in remyelination: axons were either hypomyelinated or had no myelin sheath. NRG1-deficient axons were also found to regenerate at a slower rate. After nerve injury, the neuromuscular junction was reinnervated, but excess terminal sprouting was observed. Juxtacrine Neuregulin-1 signaling is therefore dispensable for maintenance of the myelin sheath in adult animals but has a key role in reparative processes after nerve injury.
Keywords:Aging, Axons, Myelin Sheath, Myelinated Nerve Fibers, Nerve Regeneration, Neuregulin-1, Neuromuscular Junction, Sciatic Neuropathy, Animals, Mice
Source:Journal of Neuroscience
ISSN:0270-6474
Publisher:Society for Neuroscience (U.S.A.)
Volume:31
Number:9
Page Range:3225-3233
Date:2 March 2011
Official Publication:https://doi.org/10.1523/JNEUROSCI.2568-10.2011
PubMed:View item in PubMed

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