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Notch and NF-κB signaling pathways in the biology of classical Hodgkin lymphoma

Item Type:Review
Title:Notch and NF-κB signaling pathways in the biology of classical Hodgkin lymphoma
Creators Name:Schwarzer, R. and Jundt, F.
Abstract:Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression pattern and recurrent genetic lesions. Aberrant activity of Notch signaling, a highly conserved developmental pathway, acts as a negative regulator of the B cell program in HRS cells and thereby contributes to their reprogramming. Another striking feature and the major pathogenetic mechanism in HRS cells is constitutive NF-κB activation. A number of aberrations that contribute to canonical NF-κB activity in HRS cells have been described such as genetic lesions, deregulated receptor signaling and Epstein-Barr virus (EBV) infection. The importance of Notch and NF-κB signaling for cHL pathogenesis, their potential cross-talk and implications for future therapeutic applications are being discussed.
Keywords:Notch, NF-κB, Hodgkin Lymphoma, B Cell Lymphoma, Hodgkin/Reed-Sternberg Cells, Gene Transcription, Mutations, Immunoprecipitation, Inflammatory Cells, Cytokine, Helix-Loop-Helix Proteins, Epstein-Barr Virus, Multiple Myeloma, B-Chronic Lymphocytic Leukemia, Tumor Suppressor Gene, Animals
Source:Current Molecular Medicine
Publisher:Bentham (The Netherlands)
Page Range:236-245
Date:April 2011
Official Publication:https://doi.org/10.2174/156652411795243423
PubMed:View item in PubMed

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