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Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs

Item Type:Article
Title:Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs
Creators Name:Leutz, A. and Pless, O. and Lappe, M. and Dittmar, G. and Kowenz-Leutz, E.
Abstract:C/EBPs regulate tissue and cell type specific gene expression, proliferation and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.
Keywords:Transcription, Chromatin Remodeling, Differentiation, Histone Code, Post-Translational Modification, Signaling, Methylation, Animals
Source:Transcription
ISSN:2154-1264
Publisher:Landes Bioscience (U.S.A.)
Volume:2
Number:1
Page Range:3-8
Date:January 2011
Official Publication:https://doi.org/10.4161/trns.2.1.13510
PubMed:View item in PubMed

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