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Metabolic synchronization by traveling waves in yeast cell layers

Item Type:Article
Title:Metabolic synchronization by traveling waves in yeast cell layers
Creators Name:Schuetze, J. and Mair, T. and Hauser, M.J. and Falcke, M. and Wolf, J.
Abstract:The coordination of cellular behavior is a prerequisite of functionality of tissues and organs. Generally, this coordination occurs by signal transduction, neuronal control, or exchange of messenger molecules. The extent to which metabolic processes are involved in intercellular communication is less understood. Here, we address this question in layers of resting yeast cells and report for the first time the observation of intercellular glycolytic waves. We use a combined experimental and theoretical approach and explain the radial velocity of the waves to arise from the substrate gradient due to local substrate addition. Our results show that metabolic processes introduce an additional level of local intercellular coordination.
Keywords:Biological Models, Computer Simulation, Extracellular Space, Substrate Specificity, Yeasts
Source:Biophysical Journal
ISSN:0006-3495
Publisher:Biophysical Society (U.S.A.)
Volume:100
Number:4
Page Range:809-813
Date:16 February 2011
Official Publication:https://doi.org/10.1016/j.bpj.2010.12.3704
PubMed:View item in PubMed

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