Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study

Item Type:	Article
Title:	Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study
Creators Name:	Veauthier, C. and Radbruch, H. and Gaede, G. and Pfueller, C. and Doerr, J. and Bellmann-Strobl, J. and Wernecke, K.D. and Zipp, F. and Paul, F. and Sieb, J.
Abstract:	Background: Sleep disorders can cause tiredness. The relationship between sleep disorders and fatigue in patients with multiple sclerosis (MS) has not yet been investigated systematically. Objective: To investigate the relationship between fatigue and sleep disorders in patients with MS. Methods: Some 66 MS patients 20 to 66 years old were studied by overnight polysomnography. Using a cut-off point of 45 in the Modified Fatigue Impact Scale (MFIS), the entire cohort was stratified into a fatigued MS subgroup (n = 26) and a non-fatigued MS subgroup (n = 40). Results: Of the fatigued MS patients, 96% (n = 25) were suffering from a relevant sleep disorder, along with 60% of the non-fatigued MS patients (n = 24) (p = 0.001). Sleep-related breathing disorders were more frequent in the fatigued MS patients (27%) than in the non-fatigued MS patients (2.5%). Significantly higher MFIS values were detected in all (fatigued and non-fatigued) patients with relevant sleep disorders (mean MFIS 42.8; SD 18.3) than in patients without relevant sleep disorders (mean MFIS 20.5; SD 17.0) (p < 0.001). Suffering from a sleep disorder was associated with an increased risk of fatigue in MS (odds ratio: 18.5; 95% CI 1.6-208; p = 0.018). Conclusion: Our results demonstrate a clear and significant relationship between fatigue and sleep disorders.
Keywords:	Fatigue, Insomnia, Periodic Limb Movement Disorder, Polysomnography, Restless Legs Syndrome, Sleep Apnoea Syndromes, Tiredness
Source:	Multiple Sclerosis Journal
ISSN:	1352-4585
Publisher:	Sage Publications
Volume:	17
Number:	5
Page Range:	613-622
Date:	May 2011
Official Publication:	https://doi.org/10.1177/1352458510393772
PubMed:	View item in PubMed

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