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The molecular and cellular identity of peripheral osmoreceptors

Official URL:https://doi.org/10.1016/j.neuron.2010.12.028
PubMed:View item in PubMed
Creators Name:Lechner, S.G. and Markworth, S. and Poole, K. and Smith, E.S.J. and Lapatsina, L. and Frahm, S. and May, M. and Pischke, S. and Suzuki, M. and Ibanez-Tallon, I. and Luft, F.C. and Jordan, J. and Lewin, G.R.
Journal Title:Neuron
Journal Abbreviation:Neuron
Volume:69
Number:2
Page Range:332-344
Date:27 January 2011
Keywords:Afferent Neurons, Calcium, Chemoreceptor Cells, Cultured Cells, Drinking, Extracellular Fluid, Homeostasis, Inbred C57BL Mice, Knockout Mice, Liver, Osmolar Concentration, Patch-Clamp Techniques, Phorbols, Spinal Ganglia, TRPV Cation Channels, Water-Electrolyte Balance, Animals, Mice
Abstract:In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drinking water which may be mediated by peripheral osmoreceptors. Here, we identified afferent neurons in the thoracic dorsal root ganglia (DRG) of mice that innervate hepatic blood vessels and detect physiological hypo-osmotic shifts in blood osmolality. Hepatic sensory neurons are equipped with an inward current that faithfully transduces graded changes in osmolality within the physiological range (∼15 mOsm). In mice lacking the osmotically activated ion channel, TRPV4, hepatic sensory neurons no longer exhibit osmosensitive inward currents and activation of peripheral osmoreceptors in vivo is abolished. We have thus identified a new population of sensory neurons that transduce ongoing changes in hepatic osmolality.
ISSN:0896-6273
Publisher:Cell Press (U.S.A.)
Item Type:Article

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