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Mathematical analysis of a mechanism for autonomous metabolic oscillations in continuous culture of Saccharomyces cerevisiae

Item Type:Article
Title:Mathematical analysis of a mechanism for autonomous metabolic oscillations in continuous culture of Saccharomyces cerevisiae
Creators Name:Wolf, J. and Sohn, H. and Heinrich, R. and Kuriyama, H.
Abstract:Autonomous metabolic oscillations were observed in aerobic continuous culture of Saccharomyces cerevisiae. Experimental investigation of the underlying mechanism revealed that several pathways and regulatory couplings are involved. Here a hypothetical mechanism including the sulfate assimilation pathway, ethanol degradation and respiration is transformed into a mathematical model. Simulations confirm the ability of the model to produce limit cycle oscillations which reproduce most of the characteristic features of the system.
Keywords:Metabolic Oscillation, Mathematical Model, Sulfate Assimilation, Regulation of Respiration, Hydrogen Sulfide, Saccharomyces Cerevisiae
Source:FEBS Letters
ISSN:0014-5793
Publisher:Elsevier (The Netherlands)
Volume:499
Number:3
Page Range:230-234
Date:22 June 2001
Official Publication:https://doi.org/10.1016/S0014-5793(01)02562-5
PubMed:View item in PubMed

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