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Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and women

Item Type:Article
Title:Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and women
Creators Name:Pischon, T. and Pai, J.K. and Manson, J.E. and Hu, F.B. and Rexrode, K.M. and Hunter, D. and Rimm, E.B.
Abstract:Activation of the peroxisome proliferator-activated receptor-gamma (PPARgamma) improves insulin sensitivity and exerts antiatherogenic effects. A common alanine for proline substitution at codon 12 in the PPARG2 gene is related to lower receptor activity. Studies suggest that the A12 allele is associated with reduced risk of type 2 diabetes; however, data on the risk of coronary heart disease (CHD) are scarce and controversial.
Keywords:Diabetes, Ischemia, Angiogenesis, Microarrays
Source:Arteriosclerosis Thrombosis and Vascular Biology
ISSN:1079-5642
Publisher:American Heart Association (U.S.A.)
Volume:25
Number:8
Page Range:1654-1658
Date:August 2005
Official Publication:https://doi.org/10.1161/01.ATV.0000171993.78135.7e
PubMed:View item in PubMed

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