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Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition

Item Type:Article
Title:Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition
Creators Name:Friedenreich, C. and Cust, A. and Lahmann, P.H. and Steindorf, K. and Boutron-Ruault, M.C. and Clavel-Chapelon, F. and Mesrine, S. and Linseisen, J. and Rohrmann, S. and Boeing, H. and Pischon, T. and Tjonneland, A. and Halkjaer, J. and Overvad, K. and Mendez, M. and Redondo, M.L. and Garcia, C.M. and Larranaga, N. and Tormo, M.J. and Gurrea, A.B. and Bingham, S. and Khaw, K.T. and Allen, N. and Key, T. and Trichopoulou, A. and Vasilopoulou, E. and Trichopoulos, D. and Pala, V. and Palli, D. and Tumino, R. and Mattiello, A. and Vineis, P. and Bueno-de-Mesquita, H.B. and Peeters, P.H. and Berglund, G. and Manjer, J. and Lundin, E. and Lukanova, A. and Slimani, N. and Jenab, M. and Kaaks, R. and Riboli, E.
Abstract:Objective: To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups.Methods: Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling.Results: Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI > or = 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of > or =88 cm vs. <80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of > or =20 kg compared with stable weight (+/-3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users.Conclusion: Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.
Keywords:Anthropometry, Endometrial Cancer, Etiology, Risk Factors, Obesity, Adiposity, Mechanisms, Hormone Replacement Therapy
Source:Cancer Causes & Control
Page Range:399-413
Date:May 2007
Official Publication:https://doi.org/10.1007/s10552-006-0113-8
PubMed:View item in PubMed

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