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Physical activity and risk of endometrial cancer: the European prospective investigation into cancer and nutrition

Item Type:Article
Title:Physical activity and risk of endometrial cancer: the European prospective investigation into cancer and nutrition
Creators Name:Friedenreich, C. and Cust, A. and Lahmann, P.H. and Steindorf, K. and Boutron-Ruault, M.C. and Clavel-Chapelon, F. and Mesrine, S. and Linseisen, J. and Rohrmann, S. and Pischon, T. and Schulz, M. and Tjonneland, A. and Johnsen, N.F. and Overvad, K. and Mendez, M. and Arguelles, M.V. and Garcia, C.M. and Larranaga, N. and Chirlaque, M.D. and Ardanaz, E. and Bingham, S. and Khaw, K.T. and Allen, N. and Key, T. and Trichopoulou, A. and Dilis, V. and Trichopoulos, D. and Pala, V. and Palli, D. and Tumino, R. and Panico, S. and Vineis, P. and Bueno-de-Mesquita, H.B. and Peeters, P.H.M. and Monninkhof, E. and Berglund, G. and Manjer, J. and Slimani, N. and Ferrari, P. and Kaaks, R. and Riboli, E.
Abstract:The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analytic cohort within EPIC of 253,023 women. Cox proportional hazards models were used to estimate the associations between type of activity (total, occupational, household, recreational) and endometrial cancer risk. For total activity, women in the highest compared with the lowest quartile of activity had a risk of 0.88 (95% confidence interval (95% CI=0.61-1.27). No clear associations between each type of activity and endometrial cancer risk were found for the total study population combined. Associations were more evident in the stratified results, with premenopausal women who were active versus inactive experiencing a risk of 0.66 (95% CI=0.38-1.14) overall. Among premenopausal women, for household and recreational activities the risk estimates in the highest as compared with the lowest quartiles were, respectively, 0.48 (95% CI=0.23-0.99) and 0.78 (95% CI=0.44-1.39). No effect modification by body mass index, hormone replacement therapy, oral contraceptive use or energy intake was found. This study provides no evidence of a protective effect of increased physical activity in endometrial cancer risk in all women but some support for a benefit among premenopausal women. The relative risk reductions are most apparent for household activities.
Keywords:Physical Activity, Endometrial Cancer, Etiology, Biologic Mechanisms
Source:International Journal of Cancer
Page Range:347-355
Date:15 July 2007
Official Publication:https://doi.org/10.1002/ijc.22676
PubMed:View item in PubMed

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