Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition

Item Type:	Article
Title:	Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition
Creators Name:	Jenab, M. and Riboli, E. and Cleveland, R.J. and Norat, T. and Rinaldi, S. and Nieters, A. and Biessy, C. and Tjonneland, A. and Olsen, A. and Overvad, K. and Gronbaek, H. and Clavel-Chapelon, F. and Boutron-Ruault, M.C. and Linseisen, J. and Boeing, H. and Pischon, T. and Trichopoulos, D. and Oikonomou, E. and Trichopoulou, A. and Panico, S. and Vineis, P. and Berrino, F. and Tumino, R. and Masala, G. and Peters, P.H. and van Gils, C.H. and Bueno-de-Mesquita, H.B. and Ocke, M.C. and Lund, E. and Mendez, M.A. and Tormo, M.J. and Barricarte, A. and Martinez-Garcia, C. and Dorronsoro, M. and Quiros, J.R. and Hallmans, G. and Palmqvist, R. and Berglund, G. and Manjer, J. and Key, T. and Allen, N.E. and Bingham, S. and Khaw, K.T. and Cust, A. and Kaaks, R.
Abstract:	Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer cases were matched (age, date of blood donation, fasting status, gender, study center) to an equal number of control subjects. Relative cancer risks were estimated using conditional logistic regression models. Serum C-peptide concentration was positively associated with an increased colorectal cancer risk for the highest versus the lowest quintile (OR=1.56, 95% CI=1.16-2.09, p(trend)<0.01), which was slightly attenuated after adjustment for BMI and physical activity (OR=1.37, 95% CI=1.00-1.88, p(trend)=0.10). When stratified by anatomical site, the cancer risk was stronger in the colon (OR=1.67, 95% CI=1.14-2.46, p(trend)<0.01) than in the rectum (OR=1.42, 95% CI=0.90-2.25, p(trend)=0.35). The cancer risk estimates were not heterogeneous by gender or fasting status. No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk.
Keywords:	Colorectal Cancer, IGF, Insulin, C-Peptide, EPIC
Source:	International Journal of Cancer
ISSN:	0020-7136
Publisher:	Wiley
Volume:	121
Number:	2
Page Range:	368-376
Date:	15 July 2007
Official Publication:	https://doi.org/10.1002/ijc.22697
PubMed:	View item in PubMed

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