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Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Item Type:Article
Title:Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)
Creators Name:Linseisen, J. and Rohrmann, S. and Miller, A.B. and Bueno-de-Mesquita, H.B. and Buechner, F.L. and Vineis, P. and Agudo, A. and Gram, I.T. and Janson, L. and Krogh, V. and Overvad, K. and Rasmuson, T. and Schulz, M. and Pischon, T. and Kaaks, R. and Nieters, A. and Allen, N.E. and Key, T.J. and Bingham, S. and Khaw, K.T. and Amiano, P. and Barricarte, A. and Martinez, C. and Navarro, C. and Quiros, R. and Clavel-Chapelon, F. and Boutron-Ruault, M.C. and Touvier, M. and Peeters, P.H.M. and Berglund, G. and Hallmans, G. and Lund, E. and Palli, D. and Panico, S. and Tumino, R. and Tjonneland, A. and Olsen, A. and Trichopoulou, A. and Trichopoulos, D. and Autier, P. and Boffetta, P. and Slimani, N. and Riboli, E.
Abstract:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food frequency questionnaire data. Between 1992 and 2000, detailed information on diet and life-style of 478,590 individuals participating in EPIC was collected. During a median follow-up of 6.4 years, 1,126 lung cancer cases were observed. Multivariate Cox proportional hazard models were applied for statistical evaluation. In the whole study population, fruit consumption was significantly inversely associated with lung cancer risk while no association was found for vegetable consumption. In current smokers, however, lung cancer risk significantly decreased with higher vegetable consumption; this association became more pronounced after calibration, the hazard ratio (HR) being 0.78 (95% CI 0.62-0.98) per 100 g increase in daily vegetable consumption. In comparison, the HR per 100 g fruit was 0.92 (0.85-0.99) in the entire cohort and 0.90 (0.81-0.99) in smokers. Exclusion of cases diagnosed during the first 2 years of follow-up strengthened these associations, the HR being 0.71 (0.55-0.94) for vegetables (smokers) and 0.86 (0.78-0.95) for fruit (entire cohort). Cancer incidence decreased with higher consumption of apples and pears (entire cohort) as well as root vegetables (smokers). In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers.
Keywords:Cancer, Diet, Epidemiology, Fruit, Vegetables, Lung Cancer, Smoking
Source:International Journal of Cancer
ISSN:0020-7136
Publisher:Wiley (U.S.A.)
Volume:121
Number:5
Page Range:1103-1114
Date:1 September 2007
Official Publication:https://doi.org/10.1002/ijc.22807
PubMed:View item in PubMed

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