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Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women

Item Type:Article
Title:Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women
Creators Name:Pischon, T. and Pai, J.K. and Manson, J.E. and Hu, F.B. and Rexrode, K.M. and Hunter, D. and Rimm, E.B.
Abstract:OBJECTIVE: The objective was to examine the association of 5 common single nucleotide polymorphisms (SNPs) at the adiponectin locus with risk of coronary heart disease (CHD) in men and women. METHODS AND PROCEDURES: We genotyped five common SNPs in the adiponectin gene (rs266729, -11365C>G; rs822395, -4034A>C; rs822396, -3964A>G; rs2241766, +45T>G; and rs1501299, +276G>T) in men (Health Professionals Follow-up Study) and women (Nurses' Health Study) in a nested case control setting. Among participants free of cardiovascular disease at baseline, 266 men and 249 women developed non-fatal myocardial infarction or fatal CHD during 6 and 8 years of follow-up, respectively. In addition, 564 men had coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty. Using risk set sampling, controls were selected 2:1 matched on age, smoking, and date of blood draw. RESULTS: The -4034CC genotype was related to an increased risk of non-fatal myocardial infarction or fatal CHD compared with the AA genotype [relative risk (RR), men, 1.69; 95% confidence interval (CI), 0.99 to 2.89; women, 2.04; 95% CI, 1.20 to 3.49); however, this genotype was not related to risk of coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty or to plasma adiponectin levels. Other SNPs or haplotypes defined by the 5 SNPs were not consistently related to risk of CHD in men and women or to plasma adiponectin levels. DISCUSSION: Our study does not support the hypothesis that these 5 common SNPs in the adiponectin gene play an important role in the development of CHD among men and women, although we cannot exclude an association between the -4034CC genotype and risk of CHD.
Keywords:Genetics, Epidemiology, Coronary Heart Disease, Polymorphism
Source:Obesity
ISSN:1930-7381
Publisher:NAASO The Obesity Society (U.S.A.)
Volume:15
Number:8
Page Range:2051-2060
Date:August 2007
Official Publication:https://doi.org/10.1038/oby.2007.244
PubMed:View item in PubMed

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