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Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels

Item Type:Article
Title:Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels
Creators Name:Fisher, E. and Schulze, M.B. and Stefan, N. and Haering, H.U. and Doering, F. and Joost, H.G. and Al-Hasani, H. and Boeing, H. and Pischon, T.
Abstract:Adipose tissue is a key factor determining C-reactive protein (CRP) plasma levels. Variation at the fat-mass and obesity-associated (FTO) gene locus has been reported to be associated with increased body fat. We investigated whether the FTO rs9939609 T>A single nucleotide polymorphism might alter CRP levels in a population-based sample of 2,415 participants from a large prospective cohort study. Genotype/phenotype relationships were studied by linear trend analysis stratified by sex. The rs9939609 A-allele was significantly associated with CRP levels in both genders (men, +21%, P = 0.002; women, +14%, P = 0.01 per A-allele). The association was attenuated, but remained statistically significant after additional adjustment for BMI, waist-to-hip ratio, and other potential confounding factors (men, +14%, P = 0.03; women, +12%, P = 0.02; per A-allele). Similar results were obtained when subjects with CRP levels higher then 10 mg/l were excluded. Our data provide preliminary evidence that the FTO rs9939609 T>A polymorphism contributes to variation in plasma CRP levels independently of obesity indices.
Keywords:Alleles, C-Reactive Protein, Cohort Studies, Genotype, Linear Models, Obesity, Single Nucleotide Polymorphism, Prospective Studies, Proteins
Publisher:NAASO The Obesity Society
Page Range:330-334
Date:February 2009
Official Publication:https://doi.org/10.1038/oby.2008.465
PubMed:View item in PubMed

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