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Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations

Item Type:Article
Title:Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations
Creators Name:Jenab, M. and McKay, J. and Bueno-de-Mesquita, H.B. and van Duijnhoven, F.J. and Ferrari, P. and Slimani, N. and Jansen, E.H. and Pischon, T. and Rinaldi, S. and Tjonneland, A. and Olsen, A. and Overvad, K. and Boutron-Ruault, M.C. and Clavel-Chapelon, F. and Engel, P. and Kaaks, R. and Linseisen, J. and Boeing, H. and Fisher, E. and Trichopoulou, A. and Dilis, V. and Oustoglou, E. and Berrino, F. and Vineis, P. and Mattiello, A. and Masala, G. and Tumino, R. and Vrieling, A. and van Gils, C.H. and Peeters, P.H. and Brustad, M. and Lund, E. and Chirlaque, M.D. and Barricarte, A. and Suarez, L.R. and Molina, E. and Dorronsoro, M. and Sala, N. and Hallmans, G. and Palmqvist, R. and Roddam, A. and Key, T.J. and Khaw, K.T. and Bingham, S. and Boffetta, P. and Autier, P. and Byrnes, G. and Norat, T. and Riboli, E.
Abstract:Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake.
Keywords:Colorectal Cancer, Genetic, Vitamin D Receptor
Source:Cancer Epidemiology Biomarkers & Prevention
Publisher:American Association for Cancer Research
Page Range:2485-2491
Date:September 2009
Official Publication:https://doi.org/10.1158/1055-9965.EPI-09-0319
PubMed:View item in PubMed

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