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Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies

Item Type:Article
Title:Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies
Creators Name:Rinaldi, S. and Cleveland, R. and Norat, T. and Biessy, C. and Rohrmann, S. and Linseisen, J. and Boeing, H. and Pischon, T. and Panico, S. and Agnoli, C. and Palli, D. and Tumino, R. and Vineis, P. and Peeters, P.H. and van Gils, C.H. and Bueno-de-Mesquita, B.H. and Vrieling, A. and Allen, N.E. and Roddam, A. and Bingham, S. and Khaw, K.T. and Manjer, J. and Borgquist, S. and Dumeaux, V. and Torhild Gram, I. and Lund, E. and Trichopoulou, A. and Makrygiannis, G. and Benetou, V. and Molina, E. and Donate Suarez, I. and Barricarte Gurrea, A. and Gonzalez, C.A. and Tormo, M.J. and Altzibar, J.M. and Olsen, A. and Tjonneland, A. and Gronbaek, H. and Overvad, K. and Clavel-Chapelon, F. and Boutron-Ruault, M.C. and Morois, S. and Slimani, N. and Boffetta, P. and Jenab, M. and Riboli, E. and Kaaks, R.
Abstract:Several prospective studies have shown a moderate positive association between increasing circulating insulin-like growth factor-I (IGF-I) levels and colorectal cancer risk. However, the associations were often statistically nonsignificant, and the relationship of cancer risk with IGF-I's major binding protein, IGFBP-3, showed major discrepancies between studies. We investigated the association of colorectal cancer risk with serum IGF-I, total and intact IGFBP-3, in a case-control study nested within the EPIC cohort (1,121 cases of colorectal cancer and 1,121 matched controls). Conditional logistic regression was used to adjust for possible confounders. Our present study results were combined in a meta-analysis with those from 9 previous prospective studies to examine the overall evidence for a relationship of prediagnostic serum IGF-I with colorectal cancer risk. In the EPIC study, serum concentrations of IGF-I and IGFBP-3 showed no associations with risk of colorectal cancer overall. Only in subgroup analyses did our study show moderate positive associations of IGF-I levels with risk, either among younger participants only (and only for colon cancer) or among participants whose milk intakes were in the lowest tertile of the population distribution (RR for an increase of 100 ng/ml = 1.43 [95% CI = 1.13-1.93]). Nevertheless, in the meta-analysis a modest positive association remained between serum IGF-I and colorectal cancer risk overall (RR = 1.07 [1.01-1.14] for 1 standard deviation increase in IGF-I). Overall, data from our present study and previous prospective studies combined indicate a relatively modest association of colorectal cancer risk with serum IGF-I.
Keywords:Insulin-Like Growth Factor-I (IGF-I), Colorectal Neoplasms, Nested Case Control Study, European Prospective Investigation Into Cancer (EPIC), Meta-Analysis
Source:International Journal of Cancer
ISSN:0020-7136
Publisher:Wiley (U.S.A.)
Volume:126
Number:7
Page Range:1702-1715
Date:1 April 2010
Official Publication:https://doi.org/10.1002/ijc.24927
PubMed:View item in PubMed

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