Helmholtz Gemeinschaft


Presence of gallstones or kidney stones and risk of type 2 diabetes

Item Type:Article
Title:Presence of gallstones or kidney stones and risk of type 2 diabetes
Creators Name:Weikert, C. and Weikert, S. and Schulze, M.B. and Pischon, T. and Fritsche, A. and Bergmann, M.M. and Willich, S.N. and Boeing, H.
Abstract:Recent evidence suggests that gallstones and kidney stones are associated with insulin resistance, but the relation between stone diseases and the risk of developing type 2 diabetes mellitus is not clear. Participants in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study (Potsdam, Germany) provided information about the presence of gallstones and kidney stones at recruitment between 1994 and 1998. On biennial questionnaires, participants reported newly diagnosed type 2 diabetes mellitus, and confirmation was obtained from treating physicians. During a mean follow-up period of 7.0 years between 1994 and 2005, 849 incident cases of type 2 diabetes were identified among 25,166 participants. After adjustment for sex, age, waist circumference, and lifestyle risk factors, persons with reported gallstones (n = 3,293) had an increased risk of type 2 diabetes (relative risk = 1.42, 95% confidence interval: 1.21, 1.68). Among the 23,817 participants with information on reported kidney stones (784 cases of incident diabetes), those who developed kidney stones (n = 2,468) were not at increased risk of diabetes in multivariable-adjusted models (relative risk = 1.05, 95% confidence interval: 0.86, 1.27). These findings suggest that gallstones, but not kidney stones, may predict the risk of developing type 2 diabetes, providing physicians with an interventional opportunity to implement adequate prevention measures.
Keywords:Cohort Studies, Diabetes Mellitus, Type 2, Gallstones, Kidney Calculi, Insulin Resistance, Nephrolithiasis, Obesity, Risk Factors
Source:American Journal of Epidemiology
Publisher:Oxford University Press
Page Range:447-454
Date:15 February 2010
Official Publication:https://doi.org/10.1093/aje/kwp411
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library