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Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition

Item Type:Article
Title:Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition
Creators Name:Aleksandrova, K. and Jenab, M. and Boeing, H. and Jansen, E. and Bueno-de-Mesquita, H.B. and Rinaldi, S. and Riboli, E. and Overvad, K. and Dahm, C.C. and Olsen, A. and Tjonneland, A. and Boutron-Ruault, M.C. and Clavel-Chapelon, F. and Morois, S. and Palli, D. and Krogh, V. and Tumino, R. and Vineis, P. and Panico, S. and Kaaks, R. and Rohrmann, S. and Trichopoulou, A. and Lagiou, P. and Trichopoulos, D. and van Duijnhoven, F.J. and Leufkens, A.M. and Peeters, P.H. and Rodriguez, L. and Bonet, C. and Sanchez, M.J. and Dorronsoro, M. and Navarro, C. and Barricarte, A. and Palmqvist, R. and Hallmans, G. and Khaw, K.T. and Wareham, N. and Allen, N.E. and Spencer, E. and Romaguera, D. and Norat, T. and Pischon, T.
Abstract:The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of > or = 3.0 mg/L versus <1.0 mg/L were 1.36 (95% confidence interval (CI): 1.00, 1.85; P-trend = 0.01) for colon cancer and 1.02 (95% CI: 0.67, 1.57; P-trend = 0.65) for rectal cancer. Colon cancer risk was significantly increased in men (relative risk = 1.74, 95% CI: 1.11, 2.73; P-trend = 0.01) but not in women (relative risk = 1.06, 95% CI: 0.67, 1.68; P-trend = 0.13). Additional adjustment for C-peptide, glycated hemoglobin, and high density lipoprotein cholesterol did not attenuate these results. These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia.
Keywords:Colorectal Neoplasms, C-Reactive Protein, Hyperglycemia, Hyperinsulinism, Hyperlipidemias, Inflammation, Obesity, Abdominal
Source:American Journal of Epidemiology
ISSN:0002-9262
Publisher:Oxford University Press (U.K.)
Volume:172
Number:4
Page Range:407-418
Date:15 August 2010
Official Publication:https://doi.org/10.1093/aje/kwq135
PubMed:View item in PubMed

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