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Tumor necrosis factor (TNF)-alpha, soluble TNF receptors and endometrial cancer risk: The EPIC study

Item Type:Article
Title:Tumor necrosis factor (TNF)-alpha, soluble TNF receptors and endometrial cancer risk: The EPIC study
Creators Name:Dossus, L. and Becker, S. and Rinaldi, S. and Lukanova, A. and Tjønneland, A. and Olsen, A. and Overvad, K. and Chabbert-Buffet, N. and Boutron-Ruault, M.C. and Clavel-Chapelon, F. and Teucher, B. and Chang-Claude, J. and Pischon, T. and Boeing, H. and Trichopoulou, A. and Benetou, V. and Valanou, E. and Palli, D. and Sieri, S. and Tumino, R. and Sacerdote, C. and Galasso, R. and Redondo, M.L. and Bonet Bonet, C. and Molina-Montes, E. and Altzibar, J.M. and Chirlaque, M.D. and Ardanaz, E. and Bueno-de-Mesquita, H.B. and van Duijnhoven, F.J. and Peeters, P.H. and Onland-Moret, N.C. and Lundin, E. and Idahl, A. and Khaw, K.T. and Wareham, N. and Allen, N. and Romieu, I. and Fedirko, V. and Hainaut, P. and Romaguera, D. and Norat, T. and Riboli, E. and Kaaks, R.
Abstract:Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-alpha (TNF-alpha), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) to examine the association of TNF-alpha and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-alpha (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, P(trend)=0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, P(trend)=0.07), and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, P(trend)=0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated pre-diagnostic concentrations of TNF-alpha and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.
Keywords:Tumor Necrosis Factor (TNF)-alpha, Soluble TNF Receptors, Inflammation, Endometrial Cancer, Prospective
Source:International Journal of Cancer
Page Range:2032-2037
Date:15 October 2011
Official Publication:https://doi.org/10.1002/ijc.25840
PubMed:View item in PubMed

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