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Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model

Item Type:Article
Title:Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model
Creators Name:Slagman, A.C. and Bock, C. and Abdel-Aty, H. and Vogt, B. and Gebauer, F. and Janelt, G. and Wohlgemuth, F. and Morgenstern, R. and Yapici, G. and Puppe, A. and Modersohn, D. and Mans, D. and Jerichow, T. and Ott, S. and Kunze, R. and Schroedl, W. and Janko, C. and Hermann, M. and Kalden, J.R. and Kern, P. and Parsch, H. and Kirschfink, M. and Schulz-Menger, J. and Roettgen, R. and Unger, J.K. and Frei, U. and Schindler, R. and Moeckel, M. and Sheriff, A.
Abstract:Background: C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction. Methods: We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction. Results: We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by ∼70% in the established treatment system. Conclusion: We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14.
Keywords:Acute Myocardial Infarction, Acute Phase Protein, Adsorber, Apheresis, C-Reactive Protein
Source:Blood Purification
Page Range:9-17
Official Publication:https://doi.org/10.1159/000320763
PubMed:View item in PubMed

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