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| Item Type: | Article |
|---|---|
| Title: | Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model |
| Creators Name: | Slagman, A.C., Bock, C., Abdel-Aty, H., Vogt, B., Gebauer, F., Janelt, G., Wohlgemuth, F., Morgenstern, R., Yapici, G., Puppe, A., Modersohn, D., Mans, D., Jerichow, T., Ott, S., Kunze, R., Schroedl, W., Janko, C., Hermann, M., Kalden, J.R., Kern, P., Parsch, H., Kirschfink, M., Schulz-Menger, J., Roettgen, R., Unger, J.K., Frei, U., Schindler, R., Moeckel, M. and Sheriff, A. |
| Abstract: | Background: C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction. Methods: We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction. Results: We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by ∼70% in the established treatment system. Conclusion: We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14. |
| Keywords: | Acute Myocardial Infarction, Acute Phase Protein, Adsorber, Apheresis, C-Reactive Protein |
| Source: | Blood Purification |
| ISSN: | 0253-5068 |
| Publisher: | Karger |
| Volume: | 31 |
| Number: | 1-3 |
| Page Range: | 9-17 |
| Date: | 2011 |
| Official Publication: | https://doi.org/10.1159/000320763 |
| PubMed: | View item in PubMed |
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