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Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

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Item Type:Article
Title:Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance
Creators Name:Jarius, S. and Franciotta, D. and Paul, F. and Ruprecht, K. and Bergamaschi, R. and Rommer, P.S. and Reuss, R. and Probst, C. and Kristoferitsch, W. and Wandinger, K.P. and Wildemann, B.
Abstract:In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests that AQP4-Ab are directly involved in the immunopathogenesis of NMO.
Keywords:Aquaporin 4, Autoantibodies, Neuromyelitis Optica, Nonparametric Statistics, Sensitivity and Specificity
Source:Journal of Neuroinflammation
ISSN:1742-2094
Publisher:BioMed Central (U.K.)
Volume:7
Page Range:52
Date:8 September 2010
Official Publication:https://doi.org/10.1186/1742-2094-7-52
PubMed:View item in PubMed

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