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Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study

Item Type:Article
Title:Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study
Creators Name:Bock, M. and Brandt, A.U. and Doerr, J. and Pfueller, C.F. and Ohlraun, S. and Zipp, F. and Paul, F.
Abstract:Conventional time domain optical coherence tomography has been established for the in vivo assessment of retinal axonal loss in multiple sclerosis. The innovative spectral domain imaging is superior to the conventional technique with respect to data acquisition speed, resolution and reproducibility. However, until now comparability of the two techniques has not been investigated in multiple sclerosis. In this study involving 55 multiple sclerosis patients, data obtained using both techniques (Stratus time domain optical coherence tomography and Cirrus spectral domain optical coherence tomography, Carl Zeiss Meditec) showed an excellent correlation (Pearson's r = 0.926, p < 0.001). However, owing to considerable differences in absolute retinal nerve fibre layer measurements (mean +/- standard deviation 8.1 microm +/- 6.2, range -12 to 23 microm), results from the two devices are not interchangeable.
Keywords:Axonal Loss, Multiple Sclerosis
Source:Multiple Sclerosis
ISSN:1352-4585
Publisher:Sage Publications (U.K.)
Volume:16
Number:7
Page Range:893-896
Date:July 2010
Official Publication:https://doi.org/10.1177/1352458510365156
PubMed:View item in PubMed

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