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Amplification of EDHF-type vasodilatations in TRPC1-deficient mice

Item Type:Article
Title:Amplification of EDHF-type vasodilatations in TRPC1-deficient mice
Creators Name:Schmidt, K. and Dubrovska, G. and Nielsen, G. and Fesues, G. and Uhrenholt, T.R. and Hansen, P.B. and Gudermann, T. and Dietrich, A. and Gollasch, M. and de Wit, C. and Koehler, R.
Abstract:TRPC1 channels are expressed in the vasculature and are putative candidates for intracellular Ca(2+) handling. However, little is known about their role in endothelium-dependent vasodilatations including endothelium-derived hyperpolarizing factor (EDHF) vasodilatations, which require activation of Ca(2+) -activated K(+) channels (K(Ca)). To provide molecular information on the role of TRPC1 for K(Ca) function and the EDHF signalling complex, we examined endothelium-dependent and independent vasodilatations, K(Ca) currents and smooth muscle contractility in TRPC1-deficient mice (TRPC1-/-).
Keywords:Transient Receptor Potential Channels, BKCa, KCa3.1, KCa2.3, Endothelium-Derived Hyperpolarizing Factor, Endothelium, Arterial Smooth Muscle, Animals, Mice
Source:British Journal of Pharmacology
ISSN:0007-1188
Publisher:Wiley (U.K.)
Volume:161
Number:8
Page Range:1722-1733
Date:December 2010
Official Publication:https://doi.org/10.1111/j.1476-5381.2010.00985.x
PubMed:View item in PubMed

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