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Mutational analysis of the PITX2 and NKX2-5 genes in patients with idiopathic atrial fibrillation

Item Type:Letter
Title:Mutational analysis of the PITX2 and NKX2-5 genes in patients with idiopathic atrial fibrillation
Creators Name:Boldt, L.H. and Posch, M.G. and Perrot, A. and Polotzki, M. and Rolf, S. and Parwani, A.S. and Huemer, M. and Wutzler, A. and Oezcelik, C. and Haverkamp, W.
Abstract:Atrial fibrillation (AF) is the most frequently encountered arrhythmia in clinical practice. In a subgroup of patients, AF is regarded as idiopathic when no signs of structural heart disease or other causes of the arrhythmia can be identified during conventional clinical work-up. Recent studies have demonstrated that AF has a substantial genetic basis in a number of cases. The entire coding sequences, including intron-exon boundaries, of the genes PITX2 and NKX2-5 were screened for genetic variants by means of initial polymerase chain reaction followed by DNA sequencing in 96 patients with idiopathic AF. Although we detected a number of variants, our candidate gene approach did not result in identification of mutations associated with AF in the coding regions of PITX2 or NKX2-5 in our well characterized AF cohort.
Keywords:Atrial Fibrillation, Genetics, Mutation, PITX2, NKX2-5
Source:International Journal of Cardiology
ISSN:0167-5273
Publisher:Elsevier
Volume:145
Number:2
Page Range:316-317
Date:19 November 2010
Official Publication:https://doi.org/10.1016/j.ijcard.2009.11.023
PubMed:View item in PubMed

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