Mutational analysis of the PITX2 and NKX2-5 genes in patients with idiopathic atrial fibrillation

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Item Type:	Letter
Title:	Mutational analysis of the PITX2 and NKX2-5 genes in patients with idiopathic atrial fibrillation
Creators Name:	Boldt, L.H., Posch, M.G., Perrot, A., Polotzki, M., Rolf, S., Parwani, A.S., Huemer, M., Wutzler, A., Oezcelik, C. and Haverkamp, W.
Abstract:	Atrial fibrillation (AF) is the most frequently encountered arrhythmia in clinical practice. In a subgroup of patients, AF is regarded as idiopathic when no signs of structural heart disease or other causes of the arrhythmia can be identified during conventional clinical work-up. Recent studies have demonstrated that AF has a substantial genetic basis in a number of cases. The entire coding sequences, including intron-exon boundaries, of the genes PITX2 and NKX2-5 were screened for genetic variants by means of initial polymerase chain reaction followed by DNA sequencing in 96 patients with idiopathic AF. Although we detected a number of variants, our candidate gene approach did not result in identification of mutations associated with AF in the coding regions of PITX2 or NKX2-5 in our well characterized AF cohort.
Keywords:	Atrial Fibrillation, Genetics, Mutation, PITX2, NKX2-5
Source:	International Journal of Cardiology
ISSN:	0167-5273
Publisher:	Elsevier
Volume:	145
Number:	2
Page Range:	316-317
Date:	19 November 2010
Official Publication:	https://doi.org/10.1016/j.ijcard.2009.11.023
PubMed:	View item in PubMed

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