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SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease

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Item Type:Article
Title:SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease
Creators Name:Willnow, T.E. and Carlo, A.S. and Rohe, M. and Schmidt, V.
Abstract:The proteolytic breakdown of the amyloid precursor protein (APP) to neurotoxic amyloid-beta peptides in the brain has been recognized as a major pathological pathway in Alzheimer's disease (AD). Yet, the factors that control the processing of APP and their potential contribution to the common sporadic form of AD remain poorly understood. Here, we review recent findings from studies in patients and in animal models that led to the identification of a unique sorting receptor for APP in neurons, designated SORLA/SORL1, that emerges as a key player in amyloidogenic processing and as major genetic risk factor for AD.
Keywords:APP, BDNF, Neurodegeneration, Protein Trafficking, SORLA/LRI1, Secretases, VPS10P Domain
Source:Reviews in the Neurosciences
Publisher:Freund Publishing House
Page Range:315-329
Additional Information:The final publication is available at www.degruyter.com
Official Publication:https://doi.org/10.1515/REVNEURO.2010.21.4.315
PubMed:View item in PubMed

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