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Repeat-element driven activation of proto-oncogenes in human malignancies

Item Type:Article
Title:Repeat-element driven activation of proto-oncogenes in human malignancies
Creators Name:Lamprecht, B. and Bonifer, C. and Mathas, S.
Abstract:Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.
Keywords:LTR, Hodgkin Lymphoma, CSF-1 Receptor, Epigenetic Reprogramming, DNA Methylation
Source:Cell Cycle
ISSN:1538-4101
Publisher:Landes Bioscience (U.S.A.)
Volume:9
Number:21
Page Range:4276-4281
Date:November 2010
Official Publication:https://doi.org/10.4161/cc.9.21.13682
PubMed:View item in PubMed

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