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The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

Item Type:Article
Title:The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes
Creators Name:Stittrich, A.B. and Haftmann, C. and Sgouroudis, E. and Kuehl, A.A. and Hegazy, A.N. and Panse, I. and Riedel, R. and Flossdorf, M. and Dong, J. and Fuhrmann, F. and Heinz, G.A. and Fang, Z. and Li, N. and Bissels, U. and Hatam, F. and Jahn, A. and Hammoud, B. and Matz, M. and Schulze, F.M. and Baumgrass, R. and Bosio, A. and Mollenkopf, H.J. and Gruen, J. and Thiel, A. and Chen, W. and Hoefer, T. and Loddenkemper, C. and Loehning, M. and Chang, H.D. and Rajewsky, N. and Radbruch, A. and Mashreghi, M.F.
Abstract:After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor-mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. Specific inhibition of miR-182 in helper T lymphocytes limited their population expansion in vitro and in vivo. Our results demonstrate a central role for miR-182 in the physiological regulation of IL-2-driven helper T cell-mediated immune responses and open new therapeutic possibilities.
Keywords:Arthritis, Cell Proliferation, Cultured Cells, Interleukin-2, MicroRNAs, T-Lymphocytes, Animals, Mice
Source:Nature Immunology
Publisher:Nature Publishing Group
Page Range:1057-1062
Date:November 2010
Official Publication:https://doi.org/10.1038/ni.1945
PubMed:View item in PubMed

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