A novel pharmacological approach to determining parasympathetic heart rate reserve in human subjects

Item Type:	Article
Title:	A novel pharmacological approach to determining parasympathetic heart rate reserve in human subjects
Creators Name:	Tank, J. and Heusser, K. and Diedrich, A. and Luft, F.C. and Jordan, J.
Abstract:	Severe cardiac parasympathetic dysfunction can be diagnosed using bedside tests, such as a Valsalva maneuver. However, the tests that are in use are of limited value in detecting and quantifying an early impairment in cardiac parasympathetic function. We showed that alpha-2-adrenoreceptor stimulation with clonidine combined with pharmacological baroreceptor loading unmasks impaired parasympathetic heart rate reserve before overt changes in heart rate regulation occur. The methodology could be utilized to monitor the progression of autonomic nervous system disease in studies carried out to test neuroprotective strategies.
Keywords:	Adrenergic alpha-Agonists, Age Factors, Autonomic Nervous System Diseases, Baroreflex, Blood Pressure, Clonidine, Neurological Diagnostic Techniques, Heart, Heart Rate, Parasympathetic Nervous System, Phenylephrine, Predictive Value of Tests, Time Factors
Source:	Clinical Pharmacology and Therapeutics
ISSN:	0009-9236
Publisher:	Nature Publishing Group
Volume:	88
Number:	5
Page Range:	630-633
Date:	November 2010
Official Publication:	https://doi.org/10.1038/clpt.2010.177
PubMed:	View item in PubMed

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