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Mutations affecting development of the notochord in zebrafish

Item Type:Article
Title:Mutations affecting development of the notochord in zebrafish
Creators Name:Stemple, D.L. and Solnica-Krezel, L. and Zwartkruis, F. and Neuhauss, S.C. and Schier, A.F. and Malicki, J. and Stainier, D.Y. and Abdelilah, S. and Rangini, Z. and Mountcastle-Shah, E. and Driever, W.
Abstract:The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes.
Keywords:Notochord, Floor Plate, Mesoderm, Embryogenesis, Animals, Zebrafish
Publisher:Company of Biologists
Page Range:117-128
Date:December 1996
Official Publication:http://dev.biologists.org/content/123/1/117.abstract
PubMed:View item in PubMed

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