Item Type: | Article |
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Title: | Mutations affecting development of the notochord in zebrafish |
Creators Name: | Stemple, D.L. and Solnica-Krezel, L. and Zwartkruis, F. and Neuhauss, S.C. and Schier, A.F. and Malicki, J. and Stainier, D.Y. and Abdelilah, S. and Rangini, Z. and Mountcastle-Shah, E. and Driever, W. |
Abstract: | The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes. |
Keywords: | Notochord, Floor Plate, Mesoderm, Embryogenesis, Animals, Zebrafish |
Source: | Development |
ISSN: | 0950-1991 |
Publisher: | Company of Biologists |
Volume: | 123 |
Page Range: | 117-128 |
Date: | December 1996 |
Official Publication: | http://dev.biologists.org/content/123/1/117.abstract |
PubMed: | View item in PubMed |
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