Hematopoietic mutations in the zebrafish

Item Type:	Article
Title:	Hematopoietic mutations in the zebrafish
Creators Name:	Weinstein, B.M. and Schier, A.F. and Abdelilah, S. and Malicki, J. and Solnica-Krezel, L. and Stemple, D.L. and Stainier, D.Y. and Zwartkruis, F. and Driever, W. and Fishman, M.C.
Abstract:	We have identified mutations that perturb the formation or differentiation of the first embryonic blood cells in the zebrafish embryo. These 'primitive' red blood cells originate in the intermediate cell mass of the trunk, a derivative of the dorsal lateral plate mesoderm. By transfusion of blood between embryos we demonstrate that this cohort of cells provides the embryo with all, or nearly all, of its blood cells until at least day 5 postfertilization. Larval lethal mutations generated by ENU mutagenesis affect different steps in the development of these cells. Some cause defects in precursor generation, others defects in differentiation, and others an increase in cellular photosensitivity.
Keywords:	Primitive Haematopoiesis, Mutations, Animals, Zebrafish
Source:	Development
ISSN:	0950-1991
Publisher:	Company of Biologists
Volume:	123
Page Range:	303-309
Date:	December 1996
Official Publication:	http://dev.biologists.org/content/123/1/303.abstract
PubMed:	View item in PubMed

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