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Nrg1/ErbB signaling networks in Schwann cell development and myelination

Item Type:Review
Title:Nrg1/ErbB signaling networks in Schwann cell development and myelination
Creators Name:Newbern, J. and Birchmeier, C.
Abstract:Neuregulin-1 (Nrg1) provides a key axonal signal that regulates Schwann cell proliferation, migration and myelination through binding to ErbB2/3 receptors. The analysis of a number of genetic models has unmasked fundamental mechanisms underlying the specificity of the Nrg1/ErbB signaling axis. Differential expression of Nrg1 isoforms, Nrg1 processing, and ErbB receptor localization and trafficking represent important regulatory themes in the control of Nrg1/ErbB function. Nrg1 binding to ErbB2/3 receptors results in the activation of intracellular signal transduction pathways that initiate changes in Schwann cell behavior. Here, we review data that has defined the role of key Nrg1/ErbB signaling components like Shp2, ERK1/2, FAK, Rac1/Cdc42 and calcineurin in development of the Schwann cell lineage in vivo. Many of these regulators receive converging signals from other cues that are provided by Notch, integrin or G-protein coupled receptors. Signaling by multiple extracellular factors may act as key modifiers and allow Schwann cells at different developmental stages to respond in distinct manners to the Nrg1/ErbB signal.
Keywords:Neuregulin, Shp2, Erk, Erbin, Myelination, Animals
Source:Seminars in Cell & Developmental Biology
ISSN:1084-9521
Publisher:Academic Press (U.K.)
Volume:21
Number:9
Page Range:922-988
Date:December 2010
Official Publication:https://doi.org/10.1016/j.semcdb.2010.08.008
PubMed:View item in PubMed

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