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Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events

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Item Type:Editorial
Title:Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events
Creators Name:Buening, H. and Uckert, W. and Cichutek, K. and Hawkins, R.E. and Abken, H.
Abstract:Adoptive transfer of genetically retargeted T cells provides promise in the therapy of malignant diseases; two severe adverse events, however, due to "on-targeted" activation of modified T cells occurred in recent trials. We here discuss the challenge to balance targeted anti-tumor responses whilst avoiding destruction of healthy tissues and the need of continued and carefully designed pre-clinical and clinical evaluations.
Keywords:Adoptive Immunotherapy, Antigen Receptors, Clinical Trials, Lymphocyte Activation, Recombinant Proteins, T-Lymphocytes, Animals, Mice
Source:Human Gene Therapy
ISSN:1043-0342
Publisher:Mary Ann Liebert (U.S.A.)
Volume:21
Number:9
Page Range:1039-1042
Date:September 2010
Official Publication:https://doi.org/10.1089/hum.2010.131
PubMed:View item in PubMed

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