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Cellular senescence predicts treatment outcome in metastasised colorectal cancer

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Item Type:Article
Title:Cellular senescence predicts treatment outcome in metastasised colorectal cancer
Creators Name:Haugstetter, A.M. and Loddenkemper, C. and Lenze, D. and Groene, J. and Standfuss, C. and Petersen, I. and Doerken, B. and Schmitt, C.A.
Abstract:Background: Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown. Methods: A senescence index (SI) was developed and used to retrospectively correlate the treatment outcome of 30 UICC stage IV colorectal cancer (CRC) patients with their SI at diagnosis. Results: 5-Fluorouracil/leucovorin-treated CRC patients achieved a significantly longer progression-free survival when presenting with SI-positive tumours before therapy (median 12.0 vs 6.0 months; P=0.044). Conclusion: Cancer cell senescence predicts treatment outcome in metastasised CRC. Prospective analyses of larger patient cohorts are needed.
Keywords:Cellular Senescence, Colorectal Cancer, Ras Mutations, Treatment Outcome
Source:British Journal of Cancer
ISSN:0007-0920
Publisher:Nature Publishing Group (U.K.)
Volume:103
Number:4
Page Range:505-509
Date:10 August 2010
Official Publication:https://doi.org/10.1038/sj.bjc.6605784
PubMed:View item in PubMed

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