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The shunt problem: control of functional shunting in normal and tumour vasculature

Official URL:https://doi.org/10.1038/nrc2895
PubMed:View item in PubMed
Creators Name:Pries, A.R. and Hoepfner, M. and Le Noble, F. and Dewhirst, M.W. and Secomb, T.W.
Journal Title:Nature Reviews Cancer
Journal Abbreviation:Nat Rev Cancer
Volume:10
Number:8
Page Range:587-593
Date:August 2010
Keywords:Biological Models, Computer Simulation, Gap Junctions, Microvessels, Neoplasms, Physiological Adaptation, Regional Blood Flow, Signal Transduction, Animals
Abstract:Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short pathways become enlarged and flow bypasses long pathways). Such adaptation requires information about tissue metabolic status to be communicated upstream to feeding vessels, through conducted responses. We propose that impaired vascular communication in tumour microvascular networks, leading to functional shunting, is a primary cause of dysfunctional microcirculation and local hypoxia in cancer. We suggest that anti-angiogenic treatment of tumours may restore vascular communication and thereby improve or normalize flow distribution in tumour vasculature.
ISSN:1474-175X
Publisher:Nature Publishing Group (U.K.)
Item Type:Review

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