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Stability of membrane bound reactions

Item Type:Article
Title:Stability of membrane bound reactions
Creators Name:Thul, R. and Falcke, M.
Abstract:We present a novel approach to the dynamics of reactions of diffusing chemical species with species fixed in space, e.g., by binding to a membrane. The nondiffusing reaction partners are clustered in areas with a diameter smaller than the diffusion length of the diffusing partner. The activated fraction of the fixed species determines the size of an active subregion of the cluster. Linear stability analysis reveals that diffusion is one of the major determinants of the stability of the dynamics. We illustrate the model concept with Ca2+ dynamics in living cells, which has release channels as fixed reaction partners. Our results suggest that spatial and temporal structures in intracellular Ca2+ dynamics are caused by fluctuations due to the small number of channels per cluster.
Keywords:Calcium, Calcium Channels, Calcium Signaling, Cell Membrane, Endoplasmic Reticulum, Inositol 1,4,5-Trisphosphate Receptors, Inositol Phosphates, Biological Models, Cytoplasmic and Nuclear Receptors
Source:Physical Review Letters
ISSN:0031-9007
Publisher:American Physical Society (U.S.A.)
Volume:93
Number:18
Page Range:188103
Date:29 October 2004
Official Publication:https://doi.org/10.1103/PhysRevLett.93.188103
PubMed:View item in PubMed

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