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Models of the inositol trisphosphate receptor

Item Type:Review
Title:Models of the inositol trisphosphate receptor
Creators Name:Sneyd, J. and Falcke, M.
Abstract:The inositol (1,4,5)-trisphosphate receptor (IPR) plays a crucial role in calcium dynamics in a wide range of cell types, and is often a central feature in quantitative models of calcium oscillations and waves. We review deterministic and stochastic mathematical models of the IPR, from the earliest ones of the 1970s and 1980s, to the most recent. The effects of IPR stochasticity on Ca2+ dynamics are briefly discussed.
Keywords:Inositol Trisphosphate Receptor, Calcium Oscillations, Mathematical Model, Calcium Waves, Stochastic Models, Adaptation, Monod-Wyman-Changeux Models, Animals
Source:Progress in Biophysics and Molecular Biology
ISSN:0079-6107
Publisher:Elsevier (The Netherlands)
Volume:89
Number:3
Page Range:207-245
Date:November 2005
Official Publication:https://doi.org/10.1016/j.pbiomolbio.2004.11.001
PubMed:View item in PubMed

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