On the role of stochastic channel behavior in intracellular Ca2+ dynamics

Item Type:	Article
Title:	On the role of stochastic channel behavior in intracellular Ca2+ dynamics
Creators Name:	Falcke, M.
Abstract:	I present a stochastic model for intracellular Ca(2+) oscillations. The model starts from stochastic binding and dissociation of Ca(2+) to binding sites on a single subunit of the IP(3)-receptor channel but is capable of simulating large numbers of clusters for many oscillation periods too. I find oscillations with variable periods ranging from 17 s to 120 s and a standard deviation well in the experimentally observed range. Long period oscillations can be perceived as nucleation phenomenon and can be observed for a large variety of single channel dynamics. Their period depends on the geometric characteristics of the cluster array. Short periods are in the range of the time scale of channel dynamics. Both long and short period oscillations occur for parameters with a nonoscillatory deterministic regime.
Keywords:	Buffers, Calcium, Calcium Channels, Calcium Signaling, Cell Membrane, Computer Simulation, Diffusion, Endoplasmic Reticulum, Inositol 1,4,5-Trisphosphate Receptors, Ion Channel Gating, Ion Transport, Biological Models, Chemical Models, Statistical Models, Cytoplasmic and Nuclear Receptors, Sensitivity and Specificity, Stochastic Processes
Source:	Biophysical Journal
ISSN:	0006-3495
Publisher:	Biophysical Society
Volume:	84
Number:	1
Page Range:	42-56
Date:	January 2003
Official Publication:	https://doi.org/10.1016/S0006-3495(03)74831-0
PubMed:	View item in PubMed

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