Discrete stochastic modeling of calcium channel dynamics

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Item Type:	Article
Title:	Discrete stochastic modeling of calcium channel dynamics
Creators Name:	Baer, M., Falcke, M., Levine, H. and Tsimring, L.S.
Abstract:	We propose a discrete stochastic model for calcium dynamics in living cells. A set of probabilities for the opening/closing of calcium channels is assumed to depend on the calcium concentration. We study this model in one dimension, analytically in the limit of a large number of channels per site N, and numerically for small N. As the number of channels per site is increased, the transition from a nonpropagating region of activity to a propagating one changes from one described by directed percolation to that of deterministic depinning in a spatially discrete system. Also, for a small number of channels a propagating calcium wave can leave behind a novel fluctuation-driven state.
Keywords:	Calcium Channels, Ion Channel Gating, Chemical Models, Probability, Stochastic Processes
Source:	Physical Review Letters
ISSN:	0031-9007
Publisher:	American Physical Society
Volume:	84
Number:	24
Page Range:	5664-5667
Date:	12 June 2000
Official Publication:	https://doi.org/10.1103/PhysRevLett.84.5664
PubMed:	View item in PubMed

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